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Glacial ice melting out of Alaska’s eroding coastline offers a glimpse into a lost climate history

Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vitro and in vivo. We identified autophagolysosomal ...

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral tracking of the African killifish across natural ...

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluorescent in situ hybridization (weMERFISH). We quantified ...

Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the hemagglutinin gene was identified decades ago as the ...

A major advance in recent decades in the social sciences has been the use of field experiments for causal evaluation of policy interventions. Such interventions might be targeted to individuals, households, or communities, and have become commonplace in development and labor economics. This has built an enormous body of knowledge of ‘what works’ as well as an understanding of mechanisms underlying ‘why it works’. If an intervention is evaluated to enhance welfare and be cost effective, then the next challenge is to understand whether the intervention will generate similar benefits at scale. Recent work has been laying the foundation for thinking about the science of scaling and understanding why interventions can fail to scale.

The growth and penetration of lithium dendrites through electrolytes and separators remain key challenges to realizing high–energy density lithium-metal batteries. Using mechanically strong electrolytes and separators has been considered a promising ...

Editors’ selections from the current scientific literature

Highlights from the Science family of journals

Profit-seeking investors could align their muncipal bond investments with conservation actions

The editors of Science are committed to humane and ethical use of animals in research. At a minimum, we require authors to meet the guidelines laid out in the US Animal Welfare Act. We also strongly encourage authors to meet the requirements of European Union Directive 210/63/EU, which is law in the United Kingdom and many European member states. European Union Directive 210/63/EU refers directly to the 3Rs (reduction, replacement, and refinement). These requirements have been posted on our “Science Journal: Editorial policies” page (1) for many years.

We appreciate Carbone’s long-standing contributions to laboratory animal welfare and thank him for his thoughtful engagement with our study. Our experimental design was developed with explicit attention to refinement and necessity. Before the study began, the monkeys were trained for audiomotor synchronization by using standard primate neuroscience methods, which allow voluntary seating, postural comfort, and substantial freedom of movement, with only minimal restraint required to ensure task precision and safety. Hydration protocols were conservative, strictly and continuously monitored, and adjusted to maintain health and normal body weight.

The study described in the Research Article “Monkeys have rhythm” by V. G. Rajendran et al. (27 November 2025, 10.1126/science. adp5220) does not appropriately balance the harm done to laboratory animals against the potential benefits of the research. Science should raise the bar for animal welfare in the papers it publishes. The requirements for Rajendran et al.—to meet the minimal standards of the US Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals (1–3)—are insufficient.

Rejecting ignorance as the cause of antibiotic overuse, a pair of sociologists find more likely explanations

A new documentary confronts the dire future of North America’s largest terminal lake

Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice

Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting

Warming oceans and evolution make fish less likely to be on the menu

Recovery of wildflower populations from extreme drought reveals hidden evolutionary resilience

The state of food security is achieved if no one has to worry whether or how they can acquire—typically purchase—healthy and nutritious meals. In theory, food security could be addressed from two sides: increasing households’ purchasing power or lowering ...