Related publications

Successful cancer immunotherapy requires a patient to mount an effective immune response against tumors; however, many cancers evade the body’s immune system. To investigate the basis for treatment failure, we examined spontaneous mouse models of ...

Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected wild birds, ...

Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat undergo extensive adipogenesis during middle age. Thus, ...

Global biodiversity targets focus on landscape and seascape connectivity as a foundational component of biodiversity conservation, including networks of connected protected areas. Recent advances allow the measurement and prediction of organismal ...

Researchers are working with people who lived through the war as teenagers to understand conflict’s long-term tolls

The latest in science and policy

On the corners of the Holborn viaduct in central London, there are four statues: Commerce, Agriculture, Fine Art, and Science. The figure representing Science looks like she should be in Ancient Greece, but she is incongruously holding a Victorian ...

Editors’ selections from the current scientific literature

Highlights from the Science family of journals

HomeScienceVol. 388, No. 6745Rallying for US scienceBack To Vol. 388, No. 6745 Full accessLetterOutside the Tower Share on Rallying for US scienceItai YanaiAuthors Info & AffiliationsScience24 Apr 2025Vol 388, Issue 6745p. 371DOI: 10.1126/science.adx5622 PREVIOUS ARTICLEUS scientists must stand togetherPreviousNEXT ARTICLEIn Science JournalsNext NotificationsBookmark ContentsReferences and Notes…

US federal support for science is eroding (1), and the future of US scientific agencies and institutions is uncertain. Simultaneously, the Trump administration is scapegoating minority groups, including immigrants, trans people, people of color, and disabled people (2–4). In the face of this federal onslaught, scientists may feel uncertain about how to respond. Speaking up may feel risky or even futile, but the risk of backlash grows with each day that silence becomes the norm (5, 6). Now is the time for scientists to ask more of each other and demand more from our institutions.

HomeScienceVol. 388, No. 6745Science, not silence: Save US economic growthBack To Vol. 388, No. 6745 Full accessLetter Share on Science, not silence: Save US economic growthPhilip Phillips [email protected]Authors Info & AffiliationsScience24 Apr 2025Vol 388, Issue 6745p. 370DOI: 10.1126/science.adx7500 PREVIOUS ARTICLEEditor’s notePreviousNEXT ARTICLEUS scientists must stand togetherNext Notifi…

On 15 September 2022, Science published the Research Article “Structural basis for strychnine activation of human bitter taste receptor TAS2R46” by W. Xu et al. (1). On 22 November 2022, an Editorial Expression of Concern alerted readers to concerns regarding fig. S10D (1). The authors have now corrected the paper, and the Editorial Expression of Concern has been replaced by an Erratum (3). As described in the Erratum, the authors repeated bioluminescence energy transfer experiments that were the basis for figs. S9, C to F, and S10D. The new data did not provide strong functional support for the structure-based suggestion of precoupling between TAS2R46 and the G protein gustducin. In the corrected version of the Research Article, Xiaoling Cao is no longer an author; figs. S9, C to F, and S10D have been removed; and the conclusions on precoupling are weaker than in the original version. The editors remain confident in the key findings of the paper: the cryo–electron microscopy structures of human TAS2R46 complexed with chimeric mini–G protein gustducin, in both strychnine-bound and apo forms.

HomeScienceVol. 388, No. 6745Science of deathBack To Vol. 388, No. 6745 Full accessBooks et al.Podcast Share on Science of deathScience24 Apr 2025Vol 388, Issue 6745p. 369DOI: 10.1126/science.adx9075 PREVIOUS ARTICLEMissed connectionsPreviousNEXT ARTICLEEditor’s noteNext NotificationsBookmark ContentsInformation & AuthorsMetrics & CitationsView OptionsReferencesFiguresTablesMediaShare Related po…

Early investigators struggled to link contagious diseases and their causative agents

An anthropologist shows why we should think beyond the binary

Documents from Congress and think tanks reflect differences in how science is cited

Synchronized catalysis breaks down silicone polymer waste into starting monomers

Age-specific adipocyte progenitors drive visceral adipose tissue expansion in middle age

Blocking erythropoietin receptor signaling in macrophages promotes antitumor immunity