Delocalized, asynchronous, closed-loop discovery of organic laser emitters | Science
Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based ...
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies | Science
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs) is inefficient and may be ...
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates | Science
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region ...
An inflamed brain can trigger psychosis. The search is on for patients who might be cured
The discovery of rogue antibodies behind paranoia, hallucinations, and other symptoms could bring a “paradigm shift” to psychiatry
News at a glance: Solar storm stuns, COVID-19 vaccine withdrawn, and fossils return to Brazil
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Inverse design of a pyrochlore lattice of DNA origami through model-driven experiments | Science
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility of self-assembling complex lattices or finite-size constructs. However, attempts so far have mostly only been successful in silico and often fail in ...
Bandgap-universal passivation enables stable perovskite solar cells with low photovoltage loss | Science
The efficiency and longevity of metal-halide perovskite solar cells are typically dictated by nonradiative defect-mediated charge recombination. In this work, we demonstrate a vapor-based amino-silane passivation that reduces photovoltage deficits to ...
Metabolic loads and the costs of metazoan reproduction | Science
Reproduction includes two energy investments—the energy in the offspring and the energy expended to make them. The former is well understood, whereas the latter is unquantified but often assumed to be small. Without understanding both investments, the ...
Global band convergence design for high-performance thermoelectric power generation in Zintls | Science
Electronic band convergence can have a beneficial impact on thermoelectric performance, but finding the right band-converged compositions is still time-consuming. We propose a method for designing a series of compositions with simultaneous band ...
In Other Journals | Science
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Self-advocacy for young African scientists | Science
Knowledge resources and financial capital are mainly concentrated in the Global North (1), whereas the Global South, particularly Africa, lacks both investment in research (2, 3) and researchers (4). As a result, less than 1% of the global research output is produced by African institutions (5). Moreover, the majority of scientific articles reporting research conducted in Africa include foreign coauthors (6, 7), and African researchers rarely attain prestigious first or last authorship positions (8). Intra-African cooperation is also rare (5). Although research investment is a systemic problem that will require changes by the governments and institutions in African countries, individual African researchers can still take steps to improve the quality and quantity of research conducted in Africa by Africans.
Building on NIH’s data sharing policy | Science
In 2023, the National Institutes of Health (NIH) implemented a new Data Management and Sharing (DMS) Policy, which aims to maximize the amount of scientific data shared (1). For all research conducted at or funded by NIH, the policy requires a DMS Plan that describes how data will be managed and shared over the life of a project, including key information such as repositories where the data will be deposited. To increase the policy’s impact, NIH should empower stakeholders by expanding the resources provided to prepare, review, and implement DMS Plans.
Undergraduate research data crucial to equity | Science
HomeScienceVol. 384, No. 6697Undergraduate research data crucial to equityBack To Vol. 384, No. 6697 Full accessLetter Share on Undergraduate research data crucial to equityDustin B. Thoman [email protected], Jessi L. Smith, [...] , Ivan A. Hernandez, Christal D. Sohl, and Miguel T. Villodas+2 authors fewerAuthors Info & AffiliationsScience16 May 2024Vol 384, Issue 6697p. 747DOI: 10.1126/science.…
The whistleblowers | Science
A bioethicist probes the costs of exposing wrongdoing in medical research
Plants in the human gaze | Science
Must other species be like us to earn our respect?
Lubert Stryer (1938—2024) | Science
Trailblazing biochemist and author
The complexity of physician power | Science
Inequitable variation in physician effort and resource use is revealed
Engineering colloidal crystals molecule by molecule | Science
DNA particles are programmed to assemble with precision into complex lattices
Tool use promotes dental health | Science
Using tools increases foraging success in sea otters and protects their teeth from damage