Highly concentrated solutions of asymmetric semiconductor magic-sized clusters (MSCs) of cadmium sulfide, cadmium selenide, and cadmium telluride were directed through a controlled drying meniscus front, resulting in the formation of chiral MSC ...
Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) methods to generate, map, and characterize SVs in ...
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into repetitive sequences, up to 1697 per cell line, which ...
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and whether scratching provides benefit to the host are largely ...
Social animals live in groups and interact volitionally in complex ways. However, little is known about neural responses under such natural conditions. Here, we investigated hippocampal CA1 neurons in a mixed-sex group of five to 10 freely behaving wild ...
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Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, which suggests that separate mechanisms are involved. In this study, we found that the transcription ...
On 3 October 2023, a multihazard cascade in the Sikkim Himalaya, India, was triggered by 14.7 million cubic meters of frozen lateral moraine collapsing into South Lhonak Lake. The impact generated an ~20-meter tsunami-like impact wave, which breached the ...
In 2021, a year before ChatGPT took the world by storm amid the excitement about generative artificial intelligence (AI), AlphaFold 2 cracked the 50-year-old protein-folding problem, predicting three-dimensional (3D) structures for more than 200 million ...
In the ancient microbial Wood-Ljungdahl pathway, carbon dioxide (CO2) is fixed in a multistep process that ends with acetyl–coenzyme A (acetyl-CoA) synthesis at the bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase complex (CODH/ACS). In ...
The origins and prehistory of domestic sheep (Ovis aries) are incompletely understood; to address this, we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Genomes from Central Türkiye ~8000 BCE are genetically ...
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In her Letter on behalf of the American Nuclear Society (ANS), Marshall suggests that the United States should not unilaterally determine security policy with regard to high-assay low-enriched uranium (HALEU). However, it is established by international treaty that nuclear security is the sovereign responsibility of individual states (1). It is also incumbent on the United States to help inform the development of international standards by carrying out early studies. This has historically been the case, as, for example, when the United States initially established standards to restrict the dissemination of HALEU to quantities less than the amount sufficient to make a nuclear weapon (2).
In their Policy Forum “The weapons potential of high-assay low-enriched uranium” (7 June 2024, p. 1071), R. S. Kemp et al. describe the potential misuse of high-assay low-enriched uranium (HALEU). The American Nuclear Society (ANS)—a professional nuclear science and technology society representing more than 10,000 members worldwide—acknowledges the importance of continually evaluating the proliferation risks associated with nuclear materials. However, we disagree with Kemp et al.’s implied recommendation that the United States decide international nuclear security policy by unilaterally redefining HALEU enriched above 10% as “weapons usable.” ANS’s position on HALEU aligns with the stance of the United Nations’ International Atomic Energy Agency (IAEA): HALEU enriched up to 20% is not considered “direct-use” material (1).
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HomeScienceVol. 387, No. 6733Rising seas endanger maritime heritageBack To Vol. 387, No. 6733 Full accessLetter Share on Rising seas endanger maritime heritageJon M. Erlandson [email protected], Scott M. Fitzpatrick, [...] , Kristina M. Gill, Patrick V. Kirch, [...] , John T. Ruiz, Victor D. Thompson, and Jason Younker+4 authors +2 authors fewerAuthors Info & AffiliationsScience30 Jan 2025Vol 387…
The historic meeting’s legacy resists simple lessons