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Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eating is controlled by a neural pathway from the peri–...

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and metabolic homeostasis (NRF2/KEAP1), we discovered an ...

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic datasets, we identified lysosomal leucine aminopeptidase (...

In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell resolution remains incomplete. Here, we developed ...

Closed, lossless optical cavities are characterized by a Hamiltonian that obeys Hermiticity, resulting in strictly real-valued resonance frequencies. By contrast, non-Hermitian wave systems are characterized by Hamiltonians with poles and zeros at ...

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HomeScienceVol. 387, No. 6741Women-driven community education in NepalBack To Vol. 387, No. 6741 Full accessLetterOutside the Tower Share on Women-driven community education in NepalArya Gautam, Sandesh Ghimire, and Aashish R. Jha [email protected]Authors Info & AffiliationsScience27 Mar 2025Vol 387, Issue 6741p. 1362 PREVIOUS ARTICLEEquitable access needed in clinical researchPreviousNEXT ARTICL…

In her News story “Cornerstone medical ethics guidelines get a major update” (1 November 2024, p. 473), C. O’Grady describes recent changes to the Declaration of Helsinki (1). Although the revision includes improvements, O’Grady explains that some issues were overlooked, such as obligations to research participants and their communities. These oversights are particularly stark in tuberculosis (TB) research, and the resulting disparities illustrate the importance of addressing inequities systemically.

HomeScienceVol. 387, No. 6741Romanian brown bear management regressesBack To Vol. 387, No. 6741 Full accessLetter Share on Romanian brown bear management regressesMihai I. Pop, Ruben Iosif, [...] , Barbara Promberger-Fürpass, Silviu Chiriac, [...] , Ágnes Keresztesi, Laurentiu Rozylowicz, and Viorel D. Popescu [email protected]+4 authors +2 authors fewerAuthors Info & AffiliationsScience27 Mar 20…

Our species’ extinction is inevitable, argues a paleontologist

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Increasing emphasis on national priorities creates tension with curiosity-driven research

A framework widely used in classical contexts provides new insights into solving an important challenge in quantum technology