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HomeScienceVol. 388, No. 6742News at a glanceBack To Vol. 388, No. 6742 Full accessIn Brief Share on News at a glanceScience3 Apr 2025Vol 388, Issue 6742pp. 10-11 PREVIOUS ARTICLEDon’t quit the long gamePreviousNEXT ARTICLEKilled NIH grants could waste billions of dollarsNext NotificationsBookmark ContentsMass firings at health agencies, grant solicitations vetted, and autism revisitedProbe that…

Living cells that produce biofuel; robots that assist factory workers; intelligent machines that guide drug discovery—these technologies are “deep” in that they achieve something extraordinary—often thought impossible—and push society forward. Indeed, so-...

Ancient DNA sheds light on a fleeting, lush interlude of North African prehistory

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New systems can identify unknown proteins in samples from diseased tissue, the environment, and archaeological sites

DOGE argues killing grants saves money, but a Science analysis suggests more than $1.4 billion in sunk research costs may produce few results

The reasons aren’t clear—and the agency’s director claims the president’s policies haven’t slowed grant awards

Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eating is controlled by a neural pathway from the peri–...

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and metabolic homeostasis (NRF2/KEAP1), we discovered an ...

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic datasets, we identified lysosomal leucine aminopeptidase (...

In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell resolution remains incomplete. Here, we developed ...

Closed, lossless optical cavities are characterized by a Hamiltonian that obeys Hermiticity, resulting in strictly real-valued resonance frequencies. By contrast, non-Hermitian wave systems are characterized by Hamiltonians with poles and zeros at ...

Urban infernos spew a unique brew of toxic smoke and ash—with unknown effects on the risk of diseases such as cancer